Insulin Resistance Starts with Iron Overload

Iron overload is a hidden driver of insulin resistance. Excess iron accumulates in key metabolic tissues like the liver, pancreas, and muscle, where it generates oxidative stress and chronic inflammation. This damages insulin receptors and impairs glucose uptake. Over time, the body becomes less responsive to insulin, setting the stage for blood sugar imbalances, fatty liver, and type 2 diabetes. Managing iron levels is a critical, yet often overlooked, step in restoring insulin sensitivity and metabolic health.