The Mechanism
Why Iron Drives Insulin Resistance
- Fenton Reaction → Excess Fe²⁺ reacts with hydrogen peroxide, producing hydroxyl radicals that damage cells.
- Glutathione depletion → Sulfur-containing amino acids are consumed faster than they can be replaced, collapsing antioxidant defenses.
- Sulfur depletion → Without enough cysteine, methionine, and taurine, glutathione cannot be regenerated, leaving iron transport proteins unprotected.
- Chromium depletion → Iron overload interferes with chromium, an essential cofactor for the Glucose Tolerance Factor (GTF). Without it, the insulin amplification system weakens, reducing insulin’s ability to move glucose into cells.
- Chronic inflammation → Excess iron raises hepcidin, trapping iron inside tissues and blocking proper recycling.
- Receptor damage → Oxidative stress damages insulin receptors, impairing their ability to respond to insulin.
- Metabolic fallout → The combined effect is glucose intolerance, fatty liver, weight gain, and progression toward type 2 diabetes
10 Signs You May Be at Risk for Diabetes
Iron overload and insulin resistance can develop silently. Warning signs include:
- Fatigue after meals
- Midsection weight gain
- Elevated triglycerides
- Low HDL cholesterol
- Dark, thickened skin patches (acanthosis nigricans)
- Brain fog or poor concentration
- Sugar and carb cravings
- High blood pressure
- Non-alcoholic fatty liver (NAFLD)
- Family history of diabetes or heart disease
How to Check: The Insulin Resistance Score
Triglycerides ÷ HDL cholesterol
You can estimate your insulin resistance risk with a simple blood test ratio:
Triglycerides ÷ HDL cholesterol
- > 1.5 → suggests insulin resistance
- < 1.5 → generally better insulin sensitivity
The Bigger Picture
Most people think insulin resistance is “just about sugar.” In reality, it often begins with iron mismanagement, sulfur depletion, and the loss of chromium-dependent insulin amplification. Without restoring these pathways, metabolic health declines.
Glucoferrin® was designed to address this root cause by:
✔ Supporting safe iron binding and transport
✔ Protecting sulfur amino acid reserves for glutathione regeneration
✔ Helping maintain chromium’s role in glucose tolerance
✔ Reducing oxidative stress and improving insulin sensitivity